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Highlights:
If prohibitionism really is driven by morality, then it is self-defeating. If you want to put the industry in the hands of dodgy dealers registered in Tuvalu or Vanuatu, if you want to guarantee Web sites without protection for children or restraints on compulsive gamblers, if you want to help money laundering and fraud, then prohibition is the policy for you.
There is another approach, which has been tested with online sales of alcohol and pornography, and been found broadly to work. Internet gambling operations know more about their punters than casinos do.
Owning a credit card is a good proxy for proof of age; each transaction is logged, so companies can tell who is betting excessively or at odd times of the day; they can tell where a computer is, and so abide by state laws.
Registered, branded, taxed gambling companies are not perfect protection against the excesses of betting, but they are the best there is.